Extracellular signal-related kinase activation during natural reward learning: a physiological role for phasic nucleus accumbens dopamine?

نویسنده

  • Jeremy J Day
چکیده

electrically stimulated using a multielectrode array (black circles). The nine color contours represent the spatial extent of electrical signals produced by each neuron (largest signal in red). Ganglion cells and their axons were labeled using a fluorescent retrograde tracer injected into the optic nerve. For more information, see the article by Sekirnjak et al. in this issue (pages 4446 – 4456). i This Week in The Journal

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Phasic mesolimbic dopamine release tracks reward seeking during expression of Pavlovian-to-instrumental transfer.

BACKGROUND Recent theories addressing mesolimbic dopamine's role in reward processing emphasize two apparently distinct functions, one in reinforcement learning (i.e., prediction error) and another in incentive motivation (i.e., the invigoration of reward seeking elicited by reward-paired cues). Here, we evaluate the latter. METHODS Using fast-scan cyclic voltammetry, we monitored, in real ti...

متن کامل

Dopamine signaling in the nucleus accumbens of animals self-administering drugs of abuse.

Abuse of psychoactive substances can lead to drug addiction. In animals, addiction is best modeled by drug self-administration paradigms. It has been proposed that the crucial common denominator for the development of drug addiction is the ability of drugs of abuse to increase extracellular concentrations of dopamine in the nucleus accumbens (NAcc). Studies using in vivo microdialysis and chron...

متن کامل

The role of dopamine in the accumbens core in the expression of Pavlovian-conditioned responses.

The role of dopamine in reward is a topic of debate. For example, some have argued that phasic dopamine signaling provides a prediction-error signal necessary for stimulus-reward learning, whereas others have hypothesized that dopamine is not necessary for learning per se, but for attributing incentive motivational value ('incentive salience') to reward cues. These psychological processes are d...

متن کامل

Regional Variation in Phasic Dopamine Release during Alcohol and Sucrose Self-Administration in Rats

While dopamine input to the dorsal striatum is well-known to be critical for action selection, including alcohol-motivated behaviors, it is unknown whether changes in phasic dopamine accompany these behaviors. Long-term alcohol abuse is believed to promote alterations in the neurocircuitry of reward learning in both ventral and dorsal striatum, potentially through increasing dopamine release. U...

متن کامل

Appetitive cue-evoked ERK signaling in the nucleus accumbens requires NMDA and D1 dopamine receptor activation and regulates CREB phosphorylation.

Conditioned stimuli (CS) can modulate reward-seeking behavior. This modulatory effect can be maladaptive and has been implicated in excessive reward seeking and relapse to drug addiction. We previously demonstrated that exposure to an appetitive CS causes an increase in the activation of extracellular signal-regulated kinase (ERK) and cyclic-AMP response-element binding protein (CREB) in the nu...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • The Journal of neuroscience : the official journal of the Society for Neuroscience

دوره 28 17  شماره 

صفحات  -

تاریخ انتشار 2008